Tag: particleshop

August 26, 2020

Formation of N-nitrosodimethylamine During the storage of Ranitidine reagent powders and tablets

Temperature-dependent formation of N-nitrosodimethylamine during the storage of ranitidine reagent powders and tablets The purpose of this study was to elucidate the effect of high-temperature storage on the stability of ranitidine, specifically with respect to the potential formation of N-nitrosodimethylamine (NDMA), which is classified as a probable human carcinogen. Commercially available ranitidine reagent powders and formulations were stored under various conditions, and subjected to LC-MS/MS analysis. When […]