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August 26, 2020

Cross-Couplings between Alkyl Halides and Grignard Reagents

By Danielle

Cobalt-Catalyzed Cross-Couplings between Alkyl Halides and Grignard Reagents

ConspectusMetal-catalyzed cross-couplings have emerged as necessary devices for the event of C-C bonds. The identification of setting pleasant catalytic packages along with huge substrate scope made these cross-couplings key reactions to entry useful molecules ranging from provides, agrochemicals to vigorous pharmaceutical parts.
They have been an increasing number of built-in in retrosynthetic plans, allowing shorter and genuine route enchancment. Palladium-catalyzed cross-couplings nonetheless largely rule the sphere, with essentially the most well-liked reactions in industrial processes being the Suzuki and Sonogashira couplings.
Nonetheless, the intensive use of palladium complexes raises plenty of points equivalent to limited belongings, excessiveprice, environmental affect, and frequent wantfor fashionable ligands. As a consequence, utilizing nonprecious and low price metallic catalysts has appeared as a model new horizon in cross-coupling enchancment.
Over the previous three a few years, a rising curiosity has thus been devoted to Fe-, Co-, Cu-, or Ni-catalyzed cross-couplings. Their pure abundance makes them cost-effective, allowing the conception of additional sustainable and cheaper chemical processes, significantly for large-scale manufacturing of vigorous molecules.
  • Together with these economical and environmental considerations, the 3d metallic catalysts moreover exhibit complementary reactivity with palladium complexes, facilitating utilizing alkyl halide companions attributable to the decrease of β-elimination side reactions.
  • Particularly, by using cobalt catalysts, fairly just a few cross-couplings between alkyl halides and organometallics have been described.
  • Nonetheless, cobalt catalysis nonetheless stays far behind palladium catalysis with regards to fame and functions, and the enlargement of the substrate scope along with the occasion of easy and durable catalytic packages stays an needed drawback.
  • In 2012, our group entered the cobalt catalysis space by rising a cobalt-catalyzed cross-coupling between C-bromo glycosides and Grignard reagents. The generality of the coupling allowed the preparation of a wide range of useful C-aryl and C-vinyl glycoside establishing blocks.
  • We then centered on the functionalization of saturated N-heterocycles, and various halo-azetidines, -pyrrolidines, and -piperidines had been effectively reacted with aryl and alkenyl Grignard reagents beneath cobalt catalysis.
  • With the goal of creating prepared useful α-aryl amides, a cobalt-catalyzed cross-coupling utilized to α-bromo amides was studied after which extended to α-bromo lactams.
  • These days, we moreover reported an setting pleasant and regular cross-coupling involving cyclopropyl- and cyclobutyl-magnesium bromides. This technique permits the alkylation of functionalized small strained rings by a wide range of main and secondary alkyl halides.
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EZ-DNA Reagents
SK8201 100preps
EUR 93.5

EZ-DNA Reagents
BS8202 100preps
EUR 88.06

Goat Anti-Camel IgG-RPE conjugate
30835-RPE 0.5 ml
EUR 263

BI-9627
HY-18071 5mg
EUR 291

BI 224436
HY-18595 5mg
EUR 533

(±)-BI-D
HY-18601 100mg
EUR 2943

BI-847325
HY-18955 100mg
EUR 1262

BI 2536
HY-50698 100mg
EUR 1229

BI-78D3
HY-10366 25mg
EUR 349

BI-6C9
HY-103661 50mg
EUR 1083

BI-D1870
HY-10510 2mg
EUR 147

BI-882370
HY-107779 100mg
EUR 1164

BI-3802
HY-108705 10mg
EUR 911

BI-3812
HY-111381 25mg
EUR 1772

BI-3663
HY-111546 1mg
EUR 681

BI-749327
HY-111925 100mg
EUR 3092

BI-409306
HY-112831 50mg
EUR 2058

BI-671800
HY-114141 100mg
EUR 3092

BI-1347
HY-120350 10mM/1mL
EUR 176

BI-167107
HY-121251 100mg
EUR 2633

BI-4464
HY-124625 10mg
EUR 911

BI 01383298
HY-124738 10mM/1mL
EUR 163

BI-4020
HY-129550 10mg
EUR 681

BI-7273
HY-100351 50mg
EUR 877

BI-9564
HY-100352 200mg
EUR 2254

BI 689648
HY-101217 25mg
EUR 2116

BI-7273
B6196-25 25 mg
EUR 437
Description: IC50: 19 and 117 nM for BRD9 and BRD7, respectively.BI-7273 is a BRD9 bromodomain inhibitor.

BI-7273
B6196-5 5 mg
EUR 168
Description: IC50: 19 and 117 nM for BRD9 and BRD7, respectively.BI-7273 is a BRD9 bromodomain inhibitor.

BI 6015
B5668-10 10 mg
EUR 179
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI 6015
B5668-5 5 mg
EUR 118
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI 6015
B5668-50 50 mg
EUR 595
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI-847325
B6014-1 1 mg
EUR 132
Description: BI 847325 is a dual inhibitor of Ras-mitogen-activated protein kinase kinases (MEK) and Aurora kinases [1,2]. BI 847325 inhibits MEK1 and MEK2 with IC50 values of 25 and 4 nM, respectively.

BI-847325
B6014-5 5 mg
EUR 242
Description: BI 847325 is a dual inhibitor of Ras-mitogen-activated protein kinase kinases (MEK) and Aurora kinases [1,2]. BI 847325 inhibits MEK1 and MEK2 with IC50 values of 25 and 4 nM, respectively.

BI-9564
B6184-1 1 mg
EUR 109
Description: IC50: 75 nM and 3.4 ?M for BRD9 and BRD7 bromodomains, respectivelyBI-9564 is a BRD9/7 specific inhibitor.BRD7 and BRD9 are two important members of the bromodomain family protein.

BI-9564
B6184-10 10 mg
EUR 293
Description: IC50: 75 nM and 3.4 ?M for BRD9 and BRD7 bromodomains, respectivelyBI-9564 is a BRD9/7 specific inhibitor.BRD7 and BRD9 are two important members of the bromodomain family protein.

BI-D1870
B2227-10 10 mg
EUR 270
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI-D1870
B2227-5.1 10 mM (in 1mL DMSO)
EUR 235
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI-D1870
B2227-50 50 mg
EUR 595
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI 78D3
B9011-10 10 mg
EUR 216
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-100 100 mg
EUR 1094
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-25 25 mg
EUR 412
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-5 5 mg
EUR 161
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-5.1 10 mM (in 1mL DMSO)
EUR 183
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-50 50 mg
EUR 676
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 2536
A3965-10 10 mg
EUR 224
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-5 5 mg
EUR 148
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-5.1 10 mM (in 1mL DMSO)
EUR 195
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-50 50 mg
EUR 595
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-S Evaluation Sample
EUR 81
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI-847325
B1589-25
EUR 805

BI-847325
B1589-5
EUR 240

BI-78D3
B1686-25
EUR 528

BI-78D3
B1686-5
EUR 175

BI-7273
B1879-25
EUR 892

BI-7273
B1879-5
EUR 262

BI-9564
B1880-25
EUR 756

BI-9564
B1880-5
EUR 229

BI-409306
B2377-25
EUR 756

BI-409306
B2377-5
EUR 229

BI-D1870
1924-1
EUR 142

BI-D1870
1924-5
EUR 370

BI 6727
2222-1
EUR 120

BI 6727
2222-5
EUR 327

BI-2536
2370-25
EUR 523

BI-2536
2370-5
EUR 175

Set of 10 Biolipidure Reagents
Biolipidure-set 10mLx10
EUR 1517
Description: Set of 10 Biolipidure Reagents, whose applications include Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Mouse IgG-PE conjugate (isotype control)
20008-PE 50 Tests
EUR 164

Rabbit IgG-PE conjugate (isotype control)
20009-PE 100 tests
EUR 225

Goat IgG-PE conjugate (isotype control)
20011-PE 100 tests
EUR 225

Monoclonal Anti-Rat IgG1-PE Conjugate
50126-PE 0.1 ml
EUR 347

RPE Antibody, FITC conjugated
1-CSB-PA853385LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RPE. Recognizes RPE from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

SR-BI Antibody
abx238215-100ug 100 ug
EUR 509

Volasertib (BI 6727)
20-abx185613
  • EUR 592.00
  • EUR 425.00
  • 10 mg
  • 5 mg

Empagliflozin (BI 10773)
A4601-10 10 mg
EUR 131
Description: Empagliflozin is a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM [1].Sodium glucose cotransporter-2 (SGLT-2) is a member of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney [2].

Empagliflozin (BI 10773)
A4601-100 100 mg
EUR 363
Description: Empagliflozin is a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM [1].Sodium glucose cotransporter-2 (SGLT-2) is a member of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney [2].

Empagliflozin (BI 10773)
A4601-5 5 mg
EUR 108
Description: Empagliflozin is a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM [1].Sodium glucose cotransporter-2 (SGLT-2) is a member of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney [2].

Empagliflozin (BI 10773)
A4601-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Empagliflozin is a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM [1].Sodium glucose cotransporter-2 (SGLT-2) is a member of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney [2].

Empagliflozin (BI 10773)
A4601-50 50 mg
EUR 247
Description: Empagliflozin is a selective inhibitor of SGLT-2 with IC50 value of 3.1 nM [1].Sodium glucose cotransporter-2 (SGLT-2) is a member of sodium glucose co-transporter family and plays a pivotal role in glucose reabsorption in the kidney [2].

Linagliptin (BI-1356)
A4034-10 10 mg
EUR 131
Description: BI1356 is a potent and competitive DPP-4 inhibitor, which exhibited DPP-4 inhibiting activity in several independent tests.

Linagliptin (BI-1356)
A4034-100 100 mg
EUR 235
Description: BI1356 is a potent and competitive DPP-4 inhibitor, which exhibited DPP-4 inhibiting activity in several independent tests.

Linagliptin (BI-1356)
A4034-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: BI1356 is a potent and competitive DPP-4 inhibitor, which exhibited DPP-4 inhibiting activity in several independent tests.

Linagliptin (BI-1356)
A4034-50 50 mg
EUR 177
Description: BI1356 is a potent and competitive DPP-4 inhibitor, which exhibited DPP-4 inhibiting activity in several independent tests.

BI-1 Antibody
3347R-100
EUR 316

Comparative analysis between a medical system and regent dipsticks in measuring pH

Targets: Urinary pH is a decisive take into consideration plenty of pathologies, there by an informative marker employed in remedy selections. Although extensively used, the urinary pH dipstick check out won’t be sufficiently right or actual for scientific selections and additional sturdy methodologies must be considered. On this analysis, we consider pH measurements when using aportable medical system and completely completely different dipstick exams.
Provides and techniques:Four pH dipstick producers and a Lit-Administration® pH Meter had been examined using enterprise buffer choices with seven distinct pH values representing the physiological differ in urine (4.66; 5.0;5.5; 6.0; 7.0; 7.5; 8.0). A statistical analysis was carried out to guage the correlation of measured versus precise values, together with validity measures as resolution,precision and accuracy.
Outcomes: Validity measures stated the prevalence of the moveable pH meter, with a decreased dispersion of data and additional precise values. Furthermore, correlation analysis reveal that the pH values obtained with the pH meter had been the closest to the buffers’ precise pH values.
Conclusion: The detailed comparative analysis launched proper right here reveal the prevalence of a conveyable pH meter to plenty of of primarily essentially the most used dipstick producers inside the clinic.Lit-Administration® pH Meter represents a reliable completely different when a monitoring of urinary pH is required, as may happen in the middle of the screening of illnesses or remedy monitoringin the clinic, along with in the middle of the self-monitoringby the affected particular person beneath expert supervision at dwelling.
Objetivos: El pH urinario es un subject decisivo en varias patologías, en consecuencia, un marcador informativo empleado en las decisiones de tratamiento. Aunque ampliamente utilizada, la tira reactiva puede no ser lo suficientemente acurada o precisa para la toma de decisiones clínicas y otras metodologías más robustas deben ser consideradas.

En este estudio,comparamos las mediciones de pH cuando usamos un dispositivo médico portátil y diferentes tiras reactivas.

MATERIALES Y MÉTODOS: Se probaron cuatro marcas de tiras reactives de pH y un medidor de pH, Lit-Administration® pH Meter, utilizando soluciones tampón comerciales con siete valores de pH distintos que representan el rango fisiológico de pH en orina (4.66; 5.0; 5.5; 6.0;7.0; 7.5; 8.0). Se realizó un análisis estadístico para evaluar la correlación de los valores medidos versus los reales, junto con las medidas de validez como resolución,precisión y exactitud.

Resultados: Las medidas de validez indicaron la superioridad del medidor de pH portátil, con una reducción de la dispersión de los datos y valores más exactos. Además, el análisis de correlación demuestra que los valores de pH obtenidos con el medidor de pH fueron los más cercanos a los valores de pH reales de los tampones.

CONCLUSIÓN: El estudio comparativo detallado presentado aquí revela la superioridad de un medidor portátil de pH frente algunas de las marcas comerciales de tiras reactivas más ampliamente usadas en las práctica clínica. El Lit-Administration® pH Meter representa una alternativa fiable cuando se necesita un monitoreo del pH urinario, como puede suceder durante la detección de enfermedades o la monitorización del tratamiento a nivel clínico, así como durante el autocontrol domiciliario del paciente, bajo supervisión profesional.

Key phrases: Cálculos renales; Dispositivo médico; Kidney stones; Lithiasis; Litiasis; Medical system; Medidor de pH; Urinary pH; Urolithiasis; Urolitiasis; pH meter; pH urinario.

NATtrol Zika Virus Stock (Qualitative) (1 mL)
TEST 1 mL
EUR 1106.64
Description: Please contact Gentaur in order to receive the datasheet of the product.

Dipeptidyl Peptidase 4 (CD26) Antibody (RPE)
abx412944-100tests 100 tests
EUR 592

Dipeptidyl Peptidase 4 (CD26) Antibody (RPE)
abx414068-100tests 100 tests
EUR 592

Dipeptidyl Peptidase 4 (CD26) Antibody (RPE)
abx414069-25tests 25 tests
EUR 314

anti- SR-BI antibody
FNab08215 100µg
EUR 548.75
Description: Antibody raised against SR-BI

Anti-Hu CD26 FITC
1F-608-T025 25 tests
EUR 122

Anti-Hu CD26 FITC
1F-608-T100 100 tests
EUR 204

EZ-DNA Reagents
SK8201 100preps
EUR 93.5

EZ-DNA Reagents
BS8202 100preps
EUR 88.06

Mouse Anti Human Cd26 Monoclonal Antibody,RPE
CABT-45831MH 100 TEST
EUR 710

Rat Anti Mouse Cd26 Monoclonal Antibody,RPE
CABT-45844RM 100 TEST
EUR 533

Dipeptidyl Peptidase 4 (CD26) Antibody (PE)
abx139398-100tests 100 tests
EUR 481

Dipeptidyl Peptidase 4 (CD26) Antibody (PE)
abx200203-100tests 100 tests
EUR 453

Goat Anti-Camel IgG-RPE conjugate
30835-RPE 0.5 ml
EUR 263

BI-9627
HY-18071 5mg
EUR 291

BI 224436
HY-18595 5mg
EUR 533

(±)-BI-D
HY-18601 100mg
EUR 2943

BI-847325
HY-18955 100mg
EUR 1262

BI 2536
HY-50698 100mg
EUR 1229

BI-78D3
HY-10366 25mg
EUR 349

BI-6C9
HY-103661 50mg
EUR 1083

BI-D1870
HY-10510 2mg
EUR 147

BI-882370
HY-107779 100mg
EUR 1164

BI-3802
HY-108705 10mg
EUR 911

BI-3812
HY-111381 25mg
EUR 1772

BI-3663
HY-111546 1mg
EUR 681

BI-749327
HY-111925 100mg
EUR 3092

BI-409306
HY-112831 50mg
EUR 2058

BI-671800
HY-114141 100mg
EUR 3092

BI-1347
HY-120350 10mM/1mL
EUR 176

BI-167107
HY-121251 100mg
EUR 2633

BI-4464
HY-124625 10mg
EUR 911

BI 01383298
HY-124738 10mM/1mL
EUR 163

BI-4020
HY-129550 10mg
EUR 681

BI-7273
HY-100351 50mg
EUR 877

BI-9564
HY-100352 200mg
EUR 2254

BI 689648
HY-101217 25mg
EUR 2116

BI-7273
B6196-25 25 mg
EUR 437
Description: IC50: 19 and 117 nM for BRD9 and BRD7, respectively.BI-7273 is a BRD9 bromodomain inhibitor.

BI-7273
B6196-5 5 mg
EUR 168
Description: IC50: 19 and 117 nM for BRD9 and BRD7, respectively.BI-7273 is a BRD9 bromodomain inhibitor.

BI 6015
B5668-10 10 mg
EUR 179
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI 6015
B5668-5 5 mg
EUR 118
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI 6015
B5668-50 50 mg
EUR 595
Description: BI 6015 is an antagonist of hepatocyte nuclear factor 4? [1]. Hepatocyte nuclear factor 4? (HNF4?) is a nuclear receptor and regulates gene expression in enterocytes, hepatocytes and pancreatic ? cells [1]. BI 6015 is a HNF4? antagonist.

BI-847325
B6014-1 1 mg
EUR 132
Description: BI 847325 is a dual inhibitor of Ras-mitogen-activated protein kinase kinases (MEK) and Aurora kinases [1,2]. BI 847325 inhibits MEK1 and MEK2 with IC50 values of 25 and 4 nM, respectively.

BI-847325
B6014-5 5 mg
EUR 242
Description: BI 847325 is a dual inhibitor of Ras-mitogen-activated protein kinase kinases (MEK) and Aurora kinases [1,2]. BI 847325 inhibits MEK1 and MEK2 with IC50 values of 25 and 4 nM, respectively.

BI-9564
B6184-1 1 mg
EUR 109
Description: IC50: 75 nM and 3.4 ?M for BRD9 and BRD7 bromodomains, respectivelyBI-9564 is a BRD9/7 specific inhibitor.BRD7 and BRD9 are two important members of the bromodomain family protein.

BI-9564
B6184-10 10 mg
EUR 293
Description: IC50: 75 nM and 3.4 ?M for BRD9 and BRD7 bromodomains, respectivelyBI-9564 is a BRD9/7 specific inhibitor.BRD7 and BRD9 are two important members of the bromodomain family protein.

BI-D1870
B2227-10 10 mg
EUR 270
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI-D1870
B2227-5.1 10 mM (in 1mL DMSO)
EUR 235
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI-D1870
B2227-50 50 mg
EUR 595
Description: BI-D1870 is a cell-permeable inhibitor of the p90 RSK isoforms with IC50 values of 31nM, 24nM, 18nM and 15nM for RSK1, RSK2, RSK3 and RSK4 respectively [1].BI-D1870 is a derivative of dihydropteridinone and found to be a remarkably specific inhibitor of RSK isoforms.

BI 78D3
B9011-10 10 mg
EUR 216
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-100 100 mg
EUR 1094
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-25 25 mg
EUR 412
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-5 5 mg
EUR 161
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-5.1 10 mM (in 1mL DMSO)
EUR 183
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 78D3
B9011-50 50 mg
EUR 676
Description: BI-78D3 is a substrate competitive inhibitor of JNK inhibitor [2].JNK is a member of the MAPK family. JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states.

BI 2536
A3965-10 10 mg
EUR 224
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-5 5 mg
EUR 148
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-5.1 10 mM (in 1mL DMSO)
EUR 195
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-50 50 mg
EUR 595
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI 2536
A3965-S Evaluation Sample
EUR 81
Description: BI 2536 is a potent, ATP-competitive, well tolerated and highly specific human polo-like kinase 1 (PLK1) inhibitor with IC value of 0.83 nM, which shows 1000-fold selectivity against other kinases [1].

BI-847325
B1589-25
EUR 805

BI-847325
B1589-5
EUR 240

BI-78D3
B1686-25
EUR 528

BI-78D3
B1686-5
EUR 175

BI-7273
B1879-25
EUR 892

BI-7273
B1879-5
EUR 262

BI-9564
B1880-25
EUR 756

BI-9564
B1880-5
EUR 229

BI-409306
B2377-25
EUR 756

BI-409306
B2377-5
EUR 229

BI-D1870
1924-1
EUR 142

BI-D1870
1924-5
EUR 370

BI 6727
2222-1
EUR 120

BI 6727
2222-5
EUR 327

BI-2536
2370-25
EUR 523

BI-2536
2370-5
EUR 175

CD26
26A-100T 100 test
EUR 349

CD26
26B-01MG 100 test
EUR 284

CD26
26CFB-100T 100 test
EUR 388

CD26
26F-100T 100 test
EUR 297

CD26
26PE-100T 100 test
EUR 362

CD26
26PP-100T 100 test
EUR 415.3

CD26
26PU-01MG 0,1 mg
EUR 219

Dipeptidyl Peptidase 4 (CD26) Antibody (FITC)
abx139400-100tests 100 tests
EUR 425

Dipeptidyl Peptidase 4 (CD26) Antibody (FITC)
abx412942-01mg 0.1 mg
EUR 509

Dipeptidyl Peptidase 4 (CD26) Antibody (FITC)
abx414066-01mg 0.1 mg
EUR 509

Dipeptidyl Peptidase 4 (CD26) Antibody (FITC)
abx200202-100tests 100 tests
EUR 398

Set of 10 Biolipidure Reagents
Biolipidure-set 10mLx10
EUR 1517
Description: Set of 10 Biolipidure Reagents, whose applications include Immunoassays, Western blots, Immunohistochemistry, Turbidimetric assays, Immunochromatography, and Bead based assays. Benefits include: No lot to lot variation, No animal derived materials, Non-specific adsorption suppression, Stabilization of immobilized antibody, Stabilization of enzyme-antibody conjugate, Enzyme-substrate reaction enhancement and aggregation reaction enhancement

Mouse IgG-PE conjugate (isotype control)
20008-PE 50 Tests
EUR 164

Rabbit IgG-PE conjugate (isotype control)
20009-PE 100 tests
EUR 225

Goat IgG-PE conjugate (isotype control)
20011-PE 100 tests
EUR 225

Monoclonal Anti-Rat IgG1-PE Conjugate
50126-PE 0.1 ml
EUR 347

RPE Antibody, FITC conjugated
1-CSB-PA853385LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against RPE. Recognizes RPE from Human. This antibody is FITC conjugated. Tested in the following application: ELISA
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